Birth of a Prion: Spontaneous Generation Revisited
نویسنده
چکیده
The proposal that the transmissible agent in prion diseases can be a conformationally altered host protein that multiplies by autocatalytic conversion has gained wide acceptance. Recent work shows that the agent, the prion, can be replicated in a cell-free system, that it can be generated de novo, and that the strain-specific properties of prions are encoded by conformational variations of the underlying protein.
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ورودعنوان ژورنال:
- Cell
دوره 122 شماره
صفحات -
تاریخ انتشار 2005